Antibiotic are active drugs utilized for human handling. in addition , antibiotics inhibit microorganisms from growth bacterial, it prevent infections that brought by bacteria. they kill bacteria or keep bacteria from copying or inhibit bacteria to grow and double so antibiotics effect on the efficiency on the structure of bacterial populations. 1there are two types of antibiotics. bacteriostatic: inhibit bacteria from reproducing and inhibit the protein synthesis for example: tetracycline is bacteriostatic antibiotic that connect to ribosomes in bacteria to block the cell from making proteins.bactericidal: it kills bacteria for example, pencilin capable to distinguish between heathly human cells and bacterial cells and is able to destroy peptidoglycan during cell division. 2 antibiotics are useful drugs if used correctly.however, antibiotic wrong use or excessive use increase amounts of bacteria resistant to antibiotics because of bacteria reproduce quickly, resistance grow fastly. those antibiotics resistant will stay after remedy and keep to divide. antibiotics have altered dramatically medicine and protected many live but bacteria is intelligent and have developed and become resistance to antibiotics. the influence of antibiotics on bacterial populations has fundamentally focus on the sides bind to human health. for example selection of antibiotic resistant mutants and spread of antibiotic resistance genes.Antibiotic resistance is the ability of microbes such as bacteria, viruses and parasites that Cause of sickness to be alive and Continuation and adapt on the environment although take several types of antibiotics. it occurs when an antibiotic has lost its ability to kill bacterial growth, in the other words, bacteria are resistant and keep to double in the presence of antibiotics 3bacterial resistance to antibiotics destroy our ability to remedy infections.resistance mechanisms can damage cellular functions, so it impact on phenotypic traits. for instance, alter in a phenotypic trait resulting from the existence of a resistance allele.these trait impacts can lead to alteration in allele frequencies through time. for instance, if a resistance mutation or plasmid give rise to bacteria to increase and split at slower rate in non-attendance of antibiotics, this can result in reduce in the frequency of bacteria with this genotype in population. 4there are several reasons for antibiotic resistancesome bacteria are able to make enzymes that are able to destroy antibioticsantibiotic removal: some bacteria have progressed to contain pump systems that are capable to export antibiotics 5antimicrobial resistance happen naturally through time. usually over genetic alteration. however, wrong use or excessive use of antimicrobials is speeding up this operation.when microorganisms alter, they are uncovered to antimicrobial drugs. as a result, the drugs become helpless in the body and rising the risk of prevalence to others.there are two paths that can occur.automatic mutation in bacterim’s DNA.antibiotics task’s is obstruction an fundamental bacterial protein. genetic alteration can remove that protein. in addition, in the target protein can block antibiotics from attaching it or if does attach, block it from obstruction or damaging the target protein.genetic alteration can also effect to raised manufacturation of the antibiotic’s target enzyme and antibiotics are unable to disrupt them. on the hand, the bacterium may make enzyme that damage antibiotic. also, the bacterium may change permeability of ots wall or cell membrane to antibiotic.      2. transfer of antibiotic resistance genethe other path for bacterium to earn resistance is for an present antibiotic resistance gene to transfer from one bacteria to another. 6to stop and dominate the prevalence of antibiotics resistance, people can: use antibiotic when prescribed by a doctors.never request antibiotics if your doctor says you don’t need them.never share antibiotics that remain from your antibiotics don’t use leftover antibiotics wash your hands, avoid connection with ill peopleprepare your food heathlyTake your entire prescription. Do it even if you start feeling better. If you stop before the infection is completely erased , those bacteria are more likely to become drug-resistant. 7

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